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Interventions Patients were randomized to receive sildenafil (n=136) or placebo (n=132) as needed, but not more than once daily, for 12 weeks. Patients took the study drug or placebo 1 hour before anticipated sexual activity. The starting dose of sildenafil citrate was 50 mg, with the option to adjust the dose to 100 mg or 25 mg based on efficacy and tolerability, to be taken as needed.
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Varied surveys have made known that at one or different time in their lives more than fifty% of the Americans have turned to alternative drugs and treatments. And while many such erectile dysfunction treatments are utilized in some Asian countries for centuries, the Western World is only currently starting to catch up.
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Researchers Stacy Mandras and Mandeep Mehra conducted a meta-analysis of studies of sexual activity in men with coronary artery disease. They found that in middle-aged men both with and without such disease, the increases in heart rate, blood pressure and respiratory rate were well within the safe range. The highest heart rate during sexual intercourse, in fact, was actually lower than the maximum heart rate achieved simply in the course of daily activity.
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One drawback to the use of these external vacuum devices is the need to assemble the equipment and the difficulty in transporting it. Many patients lose interest in using the device because of the preparations that are necessary, the lack of easy transportability, the inability to hide the tension ring, and the relative lack of spontaneity. Approximately half the men who use a vacuum device obtain very good erections, but only half of these men consistently use the device for a prolonged period.
Diabetes mellitus also causes erectile dysfunction by damaging both sensory and autonomic nerves, a condition called diabetic neuropathy. Smoking cigarettes, obesity, poor control of blood glucose levels, and having diabetes mellitus for a long time further increases the risk of erectile dysfunction in diabetes. In addition to atherosclerosis and/or neuropathy causing ED in diabetes, many diabetic men develop a myopathy (muscle disease) as their cause of ED in which the compliance of the muscle in the corpora cavernosa is decreased and clinically this presents as an inability to maintain the erection. For additional information, please read the Diabetes article.
A pump, which draws air out of the cylinder; and
Headache and nausea were the most common side effects caused by the drug.
Erectile dysfunction. The presence of normal skin sensation adequate to produce an erection is measured with this device.
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The largest published trial of sildenafil evaluated efficacy based on the previously validated International Index of Erectile Function.21 In 312 men receiving sildenafil, mean scores for the frequency of penetration and maintenance of erections after penetration increased significantly.17 A clinically significant dose-response relationship was also demonstrated: erection appropriate for intercourse was attained in 72 percent of the men receiving 25 mg, 80 percent of those receiving 50 mg, and 85 percent of men those given 100 mg of sildenafil.17
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